Gray Lab


Jon Clardy, Harvard University

Jon Clardy

The Clardy laboratory studies how naturally occurring small molecules, especially those from bacteria, control biological processes. Organizing themes include: 1) function-based discovery of microbially-produced small molecules and their roles in multilateral symbioses, 2) function-based discovery of biologically active small molecules controlling eukaryotic development, 3) genome-based discovery of bacterially-produced small molecules. The laboratory is also involved in infectious disease research especially alternative approaches to treating bacterial and fungal infections.

Clardy Lab website

Mônica T. Pupo, University of Sao Paulo

Monica Pupo

The Pupo lab research interests center on both microbial natural products chemistry and their biological and ecological significance. The laboratory is especially interested in all aspects of the discovery of novel natural products produced by symbiotic microorganisms, including endophytic and insect-associated fungi and actinobacteria. The lab is engaged in the discovery of new antibiotics, antifungal, antiparasitic, and anticancer natural products. The microorganisms are also studied in biotransformation of natural products and drugs. Other approaches of particular interest include the utilization of mixed microbial cultures and chemical epigenetic modifiers to induce the expression of silent biosynthetic pathways.

The lab is also interested in studying biosynthetic pathways by feeding experiments on both microorganisms and their host plants. The experimental procedures involve microbiological techniques for the isolation and cultivation of the microorganisms, chromatographic techniques for the isolation of the natural products, and NMR and MS experiments are extensively used for structure elucidation.

Pupo Lab website

Cameron Currie, University of Wisconsin-Madison

Cameron Currie

The Currie lab studies the symbiotic associations between animals and microbes. We utilize a cross-disciplinary approach incorporating ecological, evolutionary, genomic, and microbiological approaches to examine how microbes shape the biology of higher organisms. Our main study system is the quadripartite association between fungus-growing ants, their fungal cultivars, mutualistic bacteria, and specialized garden pathogens.

Currie Lab website

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Clardy Lab
Harvard University
Lab phone: (617) 432-2845
Fax: (617) 432-6424

Pupo Lab
University of Sao Paulo
Lab phone: +55 16 3315-4710

Currie Lab
University of Wisconsin-Madison
Lab phone: (608) 890-0237
Fax: (608) 262-9865